Peripheral nerve blocks or plexus blocks can be used when pain occurs in the territory of one or more peripheral nerves the pain may arise from primary or secondary tumour deposits or be the result of treatment eg post radiation pain or secondary complications such as pathological fracture or vascular occlusion. Nerve blocks in palliative care fiona hicks and karen h simpson abstract in most patients pain medication along with physical therapy and supportive counselling adequately controls the pain of terminal disease but in some cases pain medication fails or produces unacceptable side effects and other more invasive interventions may be used. Peripheral nerve blocks or plexus blocks can be used when pain occurs in the territory of one or more peripheral nerves the pain may arise from primary or secondary tumour deposits or be the result of treatment eg post radiation pain or secondary complications such as pathological fracture or vascular occlusion. Peripheral nerve blocks or plexus blocks can be used when pain occurs in the territory of one or more peripheral nerves the pain may arise from primary or secondary tumour deposits or be the result of treatment eg post radiation pain or secondary complications such as pathological fracture or vascular occlusion